Research Areas

My research focuses on understanding the genetic and molecular mechanisms underlying cardiovascular and skeletal muscular diseases. With expertise in stem cell biology, single-cell techniques, CRISPR editing, and mouse modeling, my investigations include identifying and characterizing functional genetic variants associated with cardiovascular diseases and related phenotypes.

1. Cardiovascular and Skeletal Muscle Diseases

  • Identifying functional genetic variants for cardiovascular diseases
  • Understanding molecular pathways influencing cardiovascular disorders
  • Developing novel approaches to generate muscle stem cells for disease modeling

2. Functional Genomics and CRISPR Technology

  • Developing CRISPR-based methods for genome editing and screening
  • Implementing single-cell genomics for high-throughput functional screening

3. Gene Regulatory Networks in Human Diseases

  • Screening regulatory variants in human diseases combined with GWAS
  • Integrating multi-omics data to understand gene regulation mechanisms in diseases
Genetic Research Illustration

Current Projects

Investigating the evolution of cardiac traits and analyzing population-specific variants and their functional impacts. Developing therapeutic strategies for cardiac diseases.

1. Genetics underlying human heart evolution and diseases

  • Investigating the evolution of cardiac traits in African populations
  • Analyzing population-specific adaptive variants and their impacts

2. Novel Methods Development

  • Developing integrative approaches for functional variant analysis
  • Implementing single-cell genomics for high-throughput screening
Heart Evolution Illustration